N N-dimethylformamide (DMF) Solvent



N N-dimethylformamide (DMF) is a commonly employed solvent for chemical reactions. The infrared spectrum of N N-dimethylformamide shows a lower C=O stretching frequency at 1675 cm than an unsubstituted C=O bond. That because of the contribution of the two possible resonance structures of an amide. And the bond order of the carbonyl C=O bond is reduced. While that of the carbon-nitrogen bond is increased.

Also, because of the partial double bond character, the rotation about the C-N axis is slow at room temperature. That makes the two methyl groups inequivalent on the NMR time scale. Then give rise to two singlets of 3 protons each at δ 2.97 and 2.88, instead of one singlet of 6 protons in the proton NMR spectrum.

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Structure Formula:

NN dimethylformamide structure formula


Item Index
Appearance Clear
General, % 99.9% Min.
Color (PT-CO), Hazen 10 Max.
Moisture, mg/kg 500
Iron, mg/kg 0.050 Max.
Acidity (HCOOH), mg/kg 10 Max.
Basicity (DMA), mg/kg 0.001
Methanol, mg/kg 20 Max.
Conductivity (25°C, 20% aqueous), μѕ/cm 2.00 Max.
pH (25°C, 20% aqueous) 6.5-8.0


The primary use of NN-dimethylformamide (DMF) is as a solvent with a low evaporation rate. NN-dimethylformamide is used in the production of acrylic fibers and plastics.

NN-dimethylformamide is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.

It is used as a reagent in the Bouveault aldehyde synthesis and in the Vilsmeier-Haack reaction, another useful method of forming aldehydes. NN-dimethylformamide penetrates most plastics and makes them swell. Dimethylformamide therefore frequently occurs as a component of paint strippers.

NN-dimethylformamide is very effective at separating and suspending carbon nanotubes and is recommended by the NIST for use in Near-infrared spectroscopy of such. It is also used in the manufacturing of solvent dyes as an important raw material. It is consumed during the reaction.

Packing and Storage:

Packed in drums of 190kg net each or 21-22 tons per ISO tank.


Reactions including the use of sodium hydride in NN Dimethylformamide (DMF) as a solvent are somewhat hazardous. Exothermic decompositions have been reported at temperatures as low as 26 °C. On a laboratory scale, any thermal runaway is usually noticed and brought under control with an ice bath. This remains a popular combination of reagents. On a pilot plant scale, on the other hand, several accidents have been reported.


DMF, dimethylformide, NN-dimethylformide, DMFA


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