Polyhexamethylene Guanidine Hydrochloride (PHMG)


Polyhexamethylene guanidine hydrochloride (PHMG) is an antibacterial polymer containing a guanidine group in its main chain. It dissolves in water easily and forms into colorless, odorless solution. This PHMG chemical can be used as a broad-spectrum and high-efficiency disinfectant. Polyhexamethylene guanidine hydrochloride is low toxic, steady, non-flammable, non-explosive, and non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.

Because of its unique bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action. PHMG disinfectant is a high molecular polymer that can easily be washed away. It is non-corrosive to the skin and can not be easily absorbed by human organs. Polyhexamethylene guanidine hydrochloride performs good biocompatibility. This chemical can be widely used in textile, animal husbandry, aquaculture, medical sterilization, and daily disinfectant.

CAS No.:


Molecular Formula:


Structural Formula:

polyhexamethylene guanidine hydrochloride structural formula


AppearanceColorless or light yellow liquidColorless or light yellow liquid
Active content25% Min.99% Min.
OdorNoneWeak amine odor
pH5-9 (25℃)10-11 (25% water solution)
Water solubilityCompleteComplete
Water insoluable0.1% Max.
Moisture0.5% Max.


Broad spectrum kills and inhibits various types of microbial.

Polyhexamethylene guanidine hydrochloride is odorless and easily dissolved in water to form a tasteless, colorless transparent solution. It can be used as a disinfectant for almost all kinds of bacteria.

Excellent stability.

Polyhexamethylene guanidine hydrochloride remains active after being heated at 280℃ for 15 min.

Non-corrosive to metals.

Polyhexamethylene guanidine hydrochloride is non-corrosive to copper, stainless steel, carbon steel, and other metals.

Sterilization mechanism:

1. The guanidine group in Polyhexamethylene guanidine hydrochloride performs a high activity, and the polymer itself is cationic. Since bacteria and viruses are usually anionic, they are easily absorbed by Polyhexamethylene guanidine hydrochloride, cannot divide and reproduce, and finally turn inactive.

2. Polyhexamethylene guanidine hydrochloride collapses the cell membrane structure and forms transmembrane stomata. Ultimately, it causes cell membrane rupture, disrupts the energy metabolism of the organism, and disables the bacteria and virus.

3. The polymer forms a film that closes off the breathing passages of microorganisms, causing them to suffocate and die.

The sterilization mechanism is not involved with the form and type of microorganisms. Even if the microorganisms mutate, the mutation will not affect their efficacy. Microorganisms do not produce resistance to Polyhexamethylene guanidine hydrochloride.

Reacting with E. coli in suspension for 5 min, the average sterilization rate of PHMG disinfectant with 1800 mg/L is 99.95%.

Reacting with staphylococcus aureus for 5 min, the average sterilization rate of PHMG disinfectant with 2400 mg/L is 99.91%.

Reacting with candida albicans for 10 min, the average sterilization rate of PHMG disinfectant with 3200 mg/L is 99.95%.

Reacting with pseudomonas aeruginosa for 10 min, the average sterilization rate of PHMG disinfectant with 500 mg/L is 99.92%.

Reacting with HIV for 5 min, PHMG disinfectant with 1000 mg/L can kill it completely.

Reacting with bacillus subtilis black variant budding cells for four hours, the average sterilization rate of PHMG disinfectant with 5000 mg/L is 99.66%.

A foreign study shows that PHMG disinfectant with 500~2500mg/L can kill corynebacterium diphtheria, salmonella, Proteus mirabilis, and fusobacterium dysentery if reacted with them for 5~15 min.

The PHMG chemical can efficiently kill many kinds of bacterial propagules. The exact effect increases by the concentration and affects duration.


Polyhexamethylene guanidine hydrochloride can efficiently kill bacterial propagules, fungi, and some viruses. PHMG can kill 99.0% E.coli on dishware after reacting for 1-5 min. It is increasingly used in disinfection products in daily life.

At the same time, Polyhexamethylene guanidine hydrochloride can also be used in disinfection of fruits and vegetables. Since fruits and vegetables are directly edible products, non-irritating is necessary for disinfection in this field. Compared with other chemical disinfection, PHMG is much more suitable.


Polyhexamethylene guanidine hydrochloride is usually formulated with other water treatment chemicals. The exact formula depends on water and equipment conditions. The recommended dosage is 146 mg/L~13.5 g/L when used as a separate disinfectant. The dosage should be determined by the exact process and method if applied in textile and printing, livestock-raising, and aquaculture.

Packing and Storage:

Store in a cool, dry, well-ventilated warehouse. Keep away from fire and heat sources. Protect from direct sunlight. The package must be sealed and not get wet. It should be stored separately from oxidizers and flammable and combustible materials.


polyhexamethyleneguanidine hydrochloride; phmg hydrochloride; phmg 25 polyhexamethylene guanidine hydrochloride.